JAK3 — Janus kinase 3
JAK3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
JAK3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | JAK-STAT Signaling Immune regulation | ARHGAP30, CELF2, DDX17, DNAJC1, GSDMD, HCLS1, MBNL1, N4BP2L2 +7 more | View in SCUBA |
| Innate lymphoid cells | NK JAK3 Signaling activation | ANKRD44, APLP2, ATP8B4, CALCOCO2, ERLEC1, FLOT1, FUT8, FYCO1 +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ANP32E, ARHGAP30, CANX, DCTN1, EPRS1, FLII, HK1, LASP1 +9 more |
About the gene
| Synonyms | JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK |
|---|---|
| Chromosome | 19: 17824780-17848071 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
| Biological process | Adaptive immunity, Immunity, Innate immunity |
Function
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A and STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.