CANX — Calnexin
CANX belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CANX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | UPR / ER Stress Protein processing & ER | CALR, CTSB, CTTN, GRN, HDLBP, HSP90B1, HSPA5, HYOU1 +10 more | View in SCUBA |
| Fibroblasts | ER Protein Folding Housekeeping | AHCYL1, CSNK1A1, HNRNPK, HSP90B1, JAK1, KDELR1, KTN1, LAMTOR1 +10 more | View in SCUBA |
| Gamma-delta T cells | ER Antigen Processing Protein processing & ER | ACLY, ATL3, ATR, DCTN1, DDB1, ERAP1, FOXJ3, ITCH +9 more | |
| Lymphatic endothelial | Glycolytic Housekeeping Housekeeping | CALCOCO2, CAP1, DPYSL2, DYNC1I2, EIF2S2, ENO1, GIMAP8, PGAM1 +1 more | View in SCUBA |
| Macrophages | ER Membrane Homeostasis Housekeeping | ATP6V1A, BNIP2, CAPZA1, CD164, CMTM6, COPB1, EXOC5, GFM1 +18 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Remodeling DNA/chromatin regulation | ANP32E, ARHGAP30, DCTN1, EPRS1, FLII, HK1, JAK3, LASP1 +9 more | |
| Pericytes | Immunoproteasome Induction Inflammatory | GRN, LY6E, NUCB1, PGK1, PSAP, PSMB8, PSMB9, SELENOW +3 more | View in SCUBA |
About the gene
| Synonyms | CNX, IP90, P90 |
|---|---|
| Chromosome | 5: 179678628-179731641 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Chaperone |
| Biological process | Host-virus interaction |
Function
Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.