Chromatin Remodeling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 18 genes have a known function matching the annotation |
Why this annotation
Top hub genes MTA2 and SMARCC2 are core subunits of NuRD and SWI/SNF chromatin remodeling complexes, respectively. ANP32E is a histone H2A.Z chaperone. SND1 is a transcriptional coactivator. OGT and OGA (neighbor M18) form the O-GlcNAc axis linking metabolism to chromatin. However, CANX, SEC61A1, STT3A indicate ER protein processing contamination into this module, and HK1 suggests glycolytic activity. Despite mixing, chromatin remodeling is the dominant theme supported by hub genes. JAK3 presence may reflect T-cell signaling context in MAIT cells. Neighboring M19 with shared chromatin regulators confirms this as part of a chromatin regulation neighborhood.
Genes
ANP32E, ARHGAP30, CANX, DCTN1, EPRS1, FLII, HK1, JAK3, LASP1, MAP4, MTA2, OGT, PRKAR1A, RNF40, SEC61A1, SMARCC2, SND1, STT3A
Most correlated modules
- Vesicle Membrane Trafficking · correlation 0.94
- RNA Splicing Processing · correlation 0.90
- Chromatin & Splicing · correlation 0.89
- Epigenetic Maintenance · correlation 0.83
- Histone Modification · correlation 0.82
- mRNA Processing Translation · correlation 0.81
- Lymphocyte Migration · correlation 0.81
- ER Protein Glycosylation · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.