IL27RA — Interleukin 27 receptor subunit alpha
IL27RA belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL27RA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Membrane adhesion remodeling migration & adhesion | ARL6IP5, ATP6V0E1, CAMK1D, CAST, CELF2, DDAH2, EMP3, FLNA +6 more | View in SCUBA |
| CD4⁺ T cells | RNA processing RNA processing | AARSD1, ABHD14A, AMD1, CALM2, CDKN2AIP, CHMP1B, FRAT1, HNRNPAB +7 more | View in SCUBA |
| Endothelial | IL-27 Receptor Signaling Inflammation | CCND3, CDC37, HOXB2, KL, MMP15, NDUFA12, SPARCL1, TMEM243 | View in SCUBA |
| Innate lymphoid cells | Endosomal Trafficking Signaling Immune regulation | ARF1, CCDC85B, CKLF, COMMD8, FAM50A, GDE1, HAX1, LSM8 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | TCR Signaling Identity TCR Signaling | ACAP1, CASP4, CD3G, CENPT, CFAP97, DPP7, FBXW5, LMF2 +10 more | |
| Pericytes | Pericyte Contractile Tone Cytoskeletal | CARD10, CARD8, EHD4, FAM110D, KANK3, LDB2, NOSTRIN, PKP4 +4 more | View in SCUBA |
About the gene
| Synonyms | CRL1, IL-27R, TCCR, WSX-1, WSX1, zcytor1 |
|---|---|
| Chromosome | 19: 14031762-14053218 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Molecular function | Receptor |
Function
Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.