IL-27 Receptor Signaling
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
The top hub gene IL27RA encodes the IL-27 receptor alpha chain. IL-27 is a cytokine with potent anti-inflammatory effects on endothelial cells, suppressing angiogenesis and inflammation. SPARCL1 (SPARC-like 1) is a marker of quiescent endothelium and is downregulated during inflammation. MMP15 is a membrane-type matrix metalloproteinase expressed in endothelium. KL (Klotho) has anti-inflammatory and anti-aging vascular functions. CCND3 (cyclin D3) regulates cell cycle. The module is significantly decreased during inflammation in both UC and CD, consistent with loss of homeostatic endothelial quiescence signaling. The IL27RA hub strongly suggests cytokine receptor-mediated anti-inflammatory signaling in endothelium.
Genes
CCND3, CDC37, HOXB2, IL27RA, KL, MMP15, NDUFA12, SPARCL1, TMEM243
Most correlated modules
- Endothelial Lipid Signaling · correlation 0.85
- Arterial EC Identity · correlation 0.83
- Venous Endothelial Identity · correlation 0.80
- Glucocorticoid Response · correlation 0.74
- Venous Endothelial Identity · correlation 0.73
- Mitophagy Stress Response · correlation 0.71
- Hypoxia-IFN Endothelial · correlation 0.70
- Capillary Endothelial Identity · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.