MHC Class II Antigen Presentation
Gene co-expression module in Goblet cells
| Category | Immune function |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
This is the highest inflammation-delta module in the batch (UC: 2.944, CD: 3.809), with strong remission reversal. All hub genes are MHC class II molecules (HLA-DRA, HLA-DPA1, HLA-DRB1, HLA-DPB1, HLA-DRB5, HLA-DQB1, HLA-DMA) and the invariant chain CD74, which are hallmarks of IFN-gamma-induced MHC class II expression on non-professional antigen-presenting cells such as epithelial cells. Additional genes include C2 (complement component 2, also IFN-gamma induced), LCN2 (lipocalin-2, acute phase/inflammatory marker in IBD), and PSMB9 (immunoproteasome subunit, IFN-gamma regulated). The module is entirely coherent (all core membership). This represents IFN-gamma-driven MHC class II upregulation on goblet cells during IBD inflammation. Neighbor M33 covers MHC class I, confirming a neighborhood of coordinated IFN-driven antigen presentation programs.
Genes
C2, CD74, HLA-DMA, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB5, LCN2, PSMB9
Most correlated modules
- MHC Class I Antigen Presentation · correlation 0.82
- Inflammatory Goblet Remodeling · correlation 0.76
- Secreted Antimicrobials · correlation 0.67
- Mucosal Innate Defense · correlation 0.67
- Nucleotide Metabolism Stress · correlation 0.50
- DUOX2 Epithelial Inflammation · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.