LIPG — Lipase G, endothelial type
LIPG belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LIPG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Procoagulant TGF-β Response Inflammation | CITED4, CSF3, EHD1, F3, LAMC1, MED24, PLEKHO1, PMEPA1 +7 more | View in SCUBA |
About the gene
| Synonyms | EDL |
|---|---|
| Chromosome | 18: 49560699-49599185 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Heparin-binding, Hydrolase |
| Biological process | Lipid degradation, Lipid metabolism |
Function
Exerts both phospholipase and triglyceride lipase activities. More active as a phospholipase than a triglyceride lipase. Hydrolyzes triglycerides, both with short-chain fatty acyl groups (tributyrin) and long-chain fatty acyl groups (triolein) with similar levels of activity toward both types of substrates. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.