Procoagulant TGF-β Response
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes SERPINE1 (PAI-1, plasminogen activator inhibitor-1, key TGF-β target and coagulation regulator), F3 (tissue factor/coagulation factor III, initiates extrinsic coagulation cascade), CSF3 (G-CSF, neutrophil mobilization cytokine), THBS1 (thrombospondin-1, anti-angiogenic, activates latent TGF-β, promotes coagulation), LIPG (endothelial lipase, vascular inflammation), PMEPA1 (TGF-β-induced transmembrane protein), and LAMC1 (laminin γ1, basement membrane). SAMD4A (translational repressor), CITED4 (CBP/p300 co-activator), and SELL (L-selectin) are additional members. SERPINE1+F3+THBS1 constitute a classic procoagulant/thromboinflammatory endothelial response, with TGF-β signaling (SERPINE1, PMEPA1, THBS1) as a likely upstream driver. Highest inflammation delta in the batch (~1.3 in UC, ~1.2 in CD), strongly reversed in remission. This represents the procoagulant arm of endothelial inflammatory activation, complementing the NF-κB (M61) and complement (M98) modules.
Genes
CITED4, CSF3, EHD1, F3, LAMC1, LIPG, MED24, PLEKHO1, PMEPA1, QPCT, RNF19B, SAMD4A, SEC24D, SELL, SERPINE1, THBS1
Most correlated modules
- Inflammatory Endothelial Activation · correlation 0.83
- NF-κB Endothelial Activation · correlation 0.82
- Wnt Angiogenic Remodeling · correlation 0.80
- Hypoxia Response · correlation 0.78
- Complement Innate Immune · correlation 0.76
- Leukocyte Recruitment Signaling · correlation 0.72
- Endothelial Cell Migration · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.