Interferon Response
Gene co-expression module in CD19⁺ B cells
| Category | Anti-viral |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes mix immune signaling and interferon-induced antiviral/PARP genes. PARP15, SP110, MORC3 are interferon-stimulated genes; FCGR2B, CD46, CD44, BCL2, TGFBR2 are B-cell surface/signaling. The presence of multiple ISG/restriction factors (PARP15, SP110, MORC3) alongside immune modulators suggests an interferon-responsive B-cell activation state. Coherence is core, uniform expression. The CD-inflammation association and ISG content point to an antiviral/interferon program.
Genes
ACAP1, ARHGAP15, BCL2, CD44, CD46, DSE, EML4, FCGR2B, GATAD1, LMBRD1, MBP, MORC3, PARP15, SESN3, SP110, TGFBR2
Most correlated modules
- Chromatin Regulation · correlation 0.86
- MHC-I Antigen Presentation · correlation 0.85
- Adhesion/Migration · correlation 0.82
- Membrane adhesion remodeling · correlation 0.79
- B cell activation · correlation 0.76
- B cell activation signaling · correlation 0.73
- Antiviral Restriction · correlation 0.73
- TNF/NF-kB response · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.