MLF1 — Myeloid leukemia factor 1
MLF1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MLF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TRIM28-ZNF Repression DNA/chromatin regulation | B4GALT4, EEA1, FSCN1, HSPA2, ISG20L2, MAP3K13, MORN3, PABPC4 +7 more | View in SCUBA |
| Fibroblasts | BMP-ID Stress Response Stress | BHLHE40, CCDC184, CFAP20, FOXC2, GADD45G, GDF15, GDNF, HAS1 +9 more | View in SCUBA |
| Glial cells | Glucocorticoid Stress Recovery Stress | ARL6IP1, EIF4A3, FAM43A, NABP1, PNRC1, SAP18, SRSF2, TSC22D3 +3 more | View in SCUBA |
About the gene
| Chromosome | 3: 158571163-158607252 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted intracellular proteins |
| Molecular function | Developmental protein, DNA-binding |
| Biological process | Cell cycle, Differentiation |
Function
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.