PNRC1 — Proline rich nuclear receptor coactivator 1

PNRC1 belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PNRC1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	B cell quiescence BCR/AP1/NFKb pathway	AREG, BTG1, CD55, CXCR4, LY9, TUBA1A, YPEL5, ZFP36L2	View in SCUBA
CD4⁺ T cells	Post-transcriptional regulation RNA processing	BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B +21 more	View in SCUBA
CD8⁺ T cells	TCR Complex Signaling TCR Signaling	ACAP1, ANXA1, CD37, CD3E, CITED2, DUSP1, EVL, LAPTM5 +4 more	View in SCUBA
Endothelial	Hypoxia Stress Response Stress	ABCA5, ALDH2, BAALC, CIRBP, EGLN3, EPB41, FARP1, FTL +7 more	View in SCUBA
Gamma-delta T cells	TCR Early Activation TCR Signaling	BTG1, BTG2, CD69, CIRBP, CXCR4, DUSP1, EIF1, ETV3 +15 more
Glial cells	Glucocorticoid Stress Recovery Stress	ARL6IP1, EIF4A3, FAM43A, MLF1, NABP1, SAP18, SRSF2, TSC22D3 +3 more	View in SCUBA
Goblet cells	mRNA Stability Control RNA processing & translation	BTG1, DNAJB6, SRSF5, TENT5C, TSC22D1, TUBA1A, TXNIP, UBXN1 +5 more	View in SCUBA
Hematopoietic progenitor cells	Megakaryocyte IFN-primed Inflammatory	COL24A1, ELK3, GBP4, GUCY1A1, HLA-E, IFI16, IQGAP2, MAML2 +2 more
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	NF-κB Signaling Inflammatory	BIRC3, ERN1, G0S2, ICAM1, IER3, IRAK2, NFKB1, PDE4B +4 more	View in SCUBA
Mucosal-associated invariant T cell	Epigenetic Chromatin Regulation DNA/chromatin regulation	ASXL1, CREBBP, FNIP1, GATAD2A, PELI1, RAPGEF1, RYBP, ZCCHC2 +1 more
Natural Killer cells	Glucocorticoid Response Immune regulation	AREG, ARF6, BCLAF1, BEX2, BEX4, ELF1, ELL2, EPC1 +11 more	View in SCUBA
Neutrophils	Neutrophil Survival Program Inflammatory	B2M, BCL2A1, CEBPB, EIF1, FTH1, FTL, H3-3A, H3-3B +2 more
Smooth muscle cells	Glucocorticoid Metallothionein Response Stress	CEBPB, CEBPD, FKBP5, MT1E, MT1M, MT1X, MT2A, TSC22D1 +3 more	View in SCUBA

About the gene

Synonyms	B4-2, PROL2, PRR2
Chromosome	6: 89080751-89085160
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	Activator
Biological process	Transcription, Transcription regulation

Function

Nuclear receptor coactivator. May play a role in signal transduction

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.