NABP1 — Nucleic acid binding protein 1
NABP1 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NABP1's module in each cell type
About the gene
| Synonyms | DKFZp667M1322, FLJ13624, FLJ22833, hSSB2, MGC111163, NABP1-OT1, OBFC2A, SOSS-B2, SSB2 |
|---|---|
| Chromosome | 2: 191678068-191741097 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | DNA damage, DNA repair |
Function
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM- dependent signaling pathways.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.