Glucocorticoid Stress Recovery
Gene co-expression module in Glial cells
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes SRSF2 (splicing factor), UBC (ubiquitin C), SAP18 (Sin3A repressor complex), EIF4A3 (splicing/RNA helicase), NABP1 (ssDNA binding), YME1L1 (mitochondrial quality control protease), TSC22D3 (GILZ — a glucocorticoid-induced leucine zipper anti-inflammatory gene), MLF1, ARL6IP1, PNRC1 (mRNA decay). TSC22D3/GILZ is a well-established glucocorticoid response and anti-inflammatory mediator; together with mRNA decay (PNRC1), RNA processing (SRSF2, EIF4A3), and ubiquitin (UBC), this module reflects a stress recovery/anti-inflammatory transcriptional program. Increased in UC remission supports a resolution-of-inflammation context.
Genes
ARL6IP1, EIF4A3, FAM43A, MLF1, NABP1, PNRC1, SAP18, SRSF2, TSC22D3, UBC, YME1L1, ZNF503
Most correlated modules
- DNA Damage Response · correlation 0.93
- Anti-proliferative mRNA Decay · correlation 0.91
- Proteostasis Stress Response · correlation 0.91
- Inflammatory Activation Response · correlation 0.90
- Integrated Stress Response · correlation 0.90
- Integrated Stress Response · correlation 0.88
- Immediate Early Gene Response · correlation 0.83
- Glial Progenitor Identity · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.