MMRN1 — Multimerin 1
MMRN1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MMRN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | ALDH1A1, ALDH3A2, ASGR1, ATP9A, BMP2K, DSP, FAM107B, KIAA1522 +12 more | View in SCUBA |
| Lymphatic endothelial | Anticoagulant Barrier endothelial development | AP2A2, ERICH1, JUP, KBTBD11, MYCT1, PARD6G, TFPI, TIMP3 | View in SCUBA |
About the gene
| Synonyms | ECM, EMILIN4, GPIa*, MMRN |
|---|---|
| Chromosome | 4: 89879532-89954629 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
Function
Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.