Anticoagulant Barrier
Gene co-expression module in Lymphatic endothelial
| Category | endothelial development |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 9 genes have a known function matching the annotation |
Why this annotation
TFPI (tissue factor pathway inhibitor) is the primary endothelial anticoagulant that inhibits the extrinsic coagulation pathway; it is highly expressed by lymphatic and vascular endothelium. MMRN1 (multimerin-1) is stored in endothelial Weibel-Palade bodies and platelets, involved in hemostasis. TIMP3 inhibits matrix metalloproteinases and is important for vascular ECM homeostasis. JUP (junction plakoglobin/γ-catenin) maintains endothelial junctional integrity. AP2A2 mediates clathrin-dependent endocytosis. PARD6G is a cell polarity regulator. KBTBD11 is a BTB-domain protein with roles in cytoskeletal regulation. MYCT1 is an endothelial-expressed gene regulated by MYC. This module reflects endothelial anticoagulant and barrier maintenance functions, consistent with the lymphatic endothelial context and neighboring vascular modules.
Genes
AP2A2, ERICH1, JUP, KBTBD11, MMRN1, MYCT1, PARD6G, TFPI, TIMP3
Most correlated modules
- Endothelial Identity · correlation 0.90
- Lymphatic Vascular Stability · correlation 0.85
- Lymphangiogenesis ECM · correlation 0.82
- Vascular Lumen Formation · correlation 0.77
- Lymphatic Specification · correlation 0.76
- Septin Cytoskeleton · correlation 0.76
- Innate Immune Activation · correlation 0.76
- Lymphatic Valve Formation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.