Venous EC Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 21 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes include SLC40A1 (iron export/ferroportin), ALDH1A1 (retinaldehyde/lipid metabolism), MMRN1 (EC-specific multimerin), LIMS1 (focal adhesion LIM protein), DSP (desmoplakin, cell junction), NECTIN3 (adhesion), MICAL2 (cytoskeletal redox). The module is upregulated in IBD inflammation and reversed in remission. ALDH1A1 and SLC40A1 point to iron/lipid metabolic activity; MMRN1, DSP, LIMS1, NECTIN3 reflect EC structural identity. Together this resembles a venous or specialized EC metabolic-identity program active in inflammatory states.
Genes
ALDH1A1, ALDH3A2, ASGR1, ATP9A, BMP2K, DSP, FAM107B, KIAA1522, LIMD2, LIMS1, MICAL2, MMRN1, NECTIN3, PLSCR4, PNPLA2, RAB11FIP5, SLC40A1, SLC43A2, TMEM98, TRAPPC6A, USP13
Most correlated modules
- Inflammatory ECM Remodeling · correlation 0.96
- Actomyosin Contractility · correlation 0.95
- NF-κB Stress Signaling · correlation 0.82
- Inflammatory Stress Response · correlation 0.79
- Arterial EC Identity · correlation 0.74
- Endothelial Chemokine Response · correlation 0.72
- Hypoxia Stress Response · correlation 0.71
- EC Cytoskeletal Scaffold · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.