NBAS — NBAS subunit of NRZ tethering complex
NBAS belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NBAS's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Sterol Transfer Lipid metabolism | CAPN13, GAREM1, GRAMD1B, MTARC2, OSBPL9, PRLR | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Progenitor Program Erythropoietic | ABCC5, CTNNBL1, MINPP1, PDCD4, PDZD8, RNF130, SLC40A1, SNX5 +3 more |
About the gene
| Synonyms | NAG |
|---|---|
| Chromosome | 2: 15166916-15561340 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Protein transport, Transport |
Function
Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. Required for normal embryonic development (By similarity). May play a role in the nonsense-mediated decay pathway of mRNAs containing premature stop codons (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.