SLC40A1 — Solute carrier family 40 member 1
SLC40A1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SLC40A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | ALDH1A1, ALDH3A2, ASGR1, ATP9A, BMP2K, DSP, FAM107B, KIAA1522 +12 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Progenitor Program Erythropoietic | ABCC5, CTNNBL1, MINPP1, NBAS, PDCD4, PDZD8, RNF130, SNX5 +3 more | |
| Macrophages | Resident Mac Identity Tissue homeostasis | ACVRL1, CCND1, CD200R1, CFD, CR1, CTSF, EMB, EPHX1 +16 more | View in SCUBA |
About the gene
| Synonyms | FPN1, HFE4, IREG1, MTP1, SLC11A3 |
|---|---|
| Chromosome | 2: 189560590-189583758 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Ion transport, Iron transport, Transport |
Function
Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis. Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.