SNX5 — Sorting nexin 5
SNX5 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SNX5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th1 IL12 response Immune regulation | ADCY3, AKIRIN2, CTNNA1, ETV7, HIVEP3, IL12RB2, JAKMIP1, PTPN1 +2 more | View in SCUBA |
| CD8⁺ T cells | Nucleocytoplasmic Transport RNA processing & translation | KHDRBS1, KPNB1, MAT2A, NFATC2IP, RBMX, SSR3, TRA2B | View in SCUBA |
| Gamma-delta T cells | Endosomal Vesicle Trafficking Housekeeping | ADRM1, CDK2AP2, CHMP1A, COA6, CYB5B, ELOVL1, GNG5, HADHB +11 more | |
| Hematopoietic progenitor cells | Erythroid Progenitor Program Erythropoietic | ABCC5, CTNNBL1, MINPP1, NBAS, PDCD4, PDZD8, RNF130, SLC40A1 +3 more | |
| Innate lymphoid cells | NK JAK3 Signaling activation | ANKRD44, APLP2, ATP8B4, CALCOCO2, ERLEC1, FLOT1, FUT8, FYCO1 +10 more | View in SCUBA |
| Macrophages | Retromer Endosomal Sorting Vesicular traficking | ABHD15, ARHGAP45, ARHGAP9, CNPY3, CRBN, CTSO, DAB2, DRAM2 +20 more | View in SCUBA |
| Monocytes | Tissue Macrophage Identity Tissue homeostasis | CMKLR1, CREBL2, CSF1R, DST, EPB41L2, SCARB2, SLC46A1 | View in SCUBA |
About the gene
| Chromosome | 20: 17941597-17968980 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Endocytosis, Host-virus interaction, Protein transport, Transport |
Function
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Acts in part as component of the retromer membrane- deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity. Involved in retrograde transport of lysosomal enzyme receptor IGF2R. May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer- independent. Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation. Plays a role in macropinocytosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.