PDZD8 — PDZ domain containing 8
PDZD8 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDZD8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TCR Threshold Regulation TCR Signaling | AGO2, ATP8A1, AUTS2, CMIP, CNOT6L, CSNK1D, FOXO1, GSPT1 +8 more | |
| Goblet cells | Chromatin Remodeling chromatin regulation & transcription | BAZ2B, BPTF, GTF2I, INSR, MYO10, RERE, TOP2B, ZKSCAN1 | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Progenitor Program Erythropoietic | ABCC5, CTNNBL1, MINPP1, NBAS, PDCD4, RNF130, SLC40A1, SNX5 +3 more | |
| Macrophages | Chromatin Epigenetic Regulation Housekeeping | ABHD17B, ANKH, ARHGAP21, CCNH, CTTNBP2NL, DMXL1, EEIG2, ELF2 +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | Post-translational Regulation Housekeeping | CCDC93, CD55, FBXO33, GALC, KCTD20, KDM2B, MGAT4A, MSL2 +8 more | |
| Neutrophils | Granulopoiesis Program Developmental | ARHGAP24, ARID1B, B4GALT5, CSGALNACT1, FLI1, IQGAP2, LYST, PHIP +5 more |
About the gene
| Synonyms | bA129M16.2, FLJ34427, PDZK8 |
|---|---|
| Chromosome | 10: 117277274-117375440 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transporters |
| Biological process | Host-virus interaction, Lipid transport, Transport |
Function
Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes. PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer. In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons. Plays an indirect role in the regulation of cell morphology and cytoskeletal organization. May inhibit herpes simplex virus 1 infection at an early stage.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.