NOXO1 — NADPH oxidase organizer 1
NOXO1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOXO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Secreted Antimicrobials Immune function | FAM3D, IFI6, IGFBP2, KLK11, KLK12, NBL1, PCSK1, REG1A +6 more | View in SCUBA |
About the gene
| Synonyms | P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28 |
|---|---|
| Chromosome | 16: 1978917-1984192 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
Function
Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.