Secreted Antimicrobials
Gene co-expression module in Goblet cells
| Category | Immune function |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 15 genes have a known function matching the annotation |
Why this annotation
The module is dominated by secreted antimicrobial proteins (REG1A, REG3A, REG1B, RETNLB, FAM3D) and defense-related secreted factors (KLK11, KLK12, SOD3, NOXO1, IGFBP2, PCSK1) with strong upregulation in UC and CD inflammation and downregulation in remission. REG family proteins are canonical IBD-induced goblet/epithelial antimicrobial lectins. RETNLB is a goblet-specific antibacterial protein. FAM3D promotes neutrophil chemotaxis. IFI6 adds a minor interferon component. The overall signature reflects an inflammation-driven antibacterial secretion program in goblet cells.
Genes
FAM3D, IFI6, IGFBP2, KLK11, KLK12, NBL1, NOXO1, PCSK1, REG1A, REG1B, REG3A, RETNLB, SOD3, TESC, TINAGL1
Most correlated modules
- Inflammatory Goblet Remodeling · correlation 0.83
- MHC Class II Antigen Presentation · correlation 0.67
- MHC Class I Antigen Presentation · correlation 0.53
- Nucleotide Metabolism Stress · correlation 0.41
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.