Arterial EC Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes JAG1 (canonical Notch ligand and arterial EC marker), BMP4 (arterial morphogen), LTBP4 (TGF-β/BMP bioavailability regulator), PCSK5 (BMP/growth factor processing proprotein convertase), and PI16 (quiescent EC marker) define an arterial endothelial identity and Notch/BMP signaling program. TSPAN2 is enriched in arterial ECs. AFAP1L2, NEBL, and SPECC1 reflect cytoskeletal organization associated with arterial identity. The module is upregulated in remission in both UC and CD, consistent with restoration of arterial EC specification after resolution of inflammation. Neighbor M110 similarly reflects homeostatic EC identity, supporting that these two modules represent complementary aspects of normal endothelial programs lost during active IBD.
Genes
AFAP1L2, BMP4, CFAP36, FUT8, ITPR2, JAG1, LTBP4, NEBL, NPTXR, PCSK5, PI16, SPECC1, TMEM178A, TRABD2A, TSPAN2
Most correlated modules
- Inflammatory ECM Remodeling · correlation 0.89
- Inflammatory Angiogenesis · correlation 0.88
- Vascular Homeostasis · correlation 0.88
- EC Inflammatory Activation · correlation 0.87
- Endothelial Quiescence · correlation 0.83
- Cytoskeletal Scaffolding · correlation 0.79
- YAP Mechanotransduction · correlation 0.73
- Arterial EC Identity · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.