JAG1 — Jagged canonical Notch ligand 1
JAG1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
JAG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Identity Endothelial cell development | AFAP1L2, BMP4, CFAP36, FUT8, ITPR2, LTBP4, NEBL, NPTXR +6 more | View in SCUBA |
| Pericytes | Myosin Phosphatase Regulation Cytoskeletal | CALM2, CRIP1, CRYAB, HCFC1R1, LBH, MAP3K7CL, PHLDA2, PLAC9 +2 more | View in SCUBA |
| Smooth muscle cells | Notch-TGFbeta Signaling Development | ACKR3, AFAP1L2, CSRNP3, GJC1, HTR1F, LRRC10B, RAP2A, SLC38A11 +3 more | View in SCUBA |
About the gene
| Synonyms | AGS, AHD, AWS, CD339, HJ1, JAGL1 |
|---|---|
| Chromosome | 20: 10637684-10673999 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Notch signaling pathway |
Function
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.