LRIG1 — Leucine rich repeats and immunoglobulin like domains 1
LRIG1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LRIG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Homeostatic Stromal Identity ECM production | ADAMTSL1, ADAMTSL3, EPB41L2, KAZALD1, NFIB, NUPR1, PDE5A, PLXDC1 +4 more | View in SCUBA |
| Gamma-delta T cells | T Cell Development T cell maturation | ANK3, ATF7IP2, CERK, ERN1, FKBP11, MICAL2, PAG1, PBXIP1 +4 more | |
| Smooth muscle cells | SMC Ion Signaling Contractility | ANTXR2, ATP1B1, CDKN1C, CENPW, FAM83D, FXYD6, GAS1, KCNMA1 +12 more | View in SCUBA |
About the gene
| Synonyms | DKFZP586O1624, LIG-1, LIG1 |
|---|---|
| Chromosome | 3: 66378797-66501263 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
Function
Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.