PDGFB — Platelet derived growth factor subunit B
PDGFB belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDGFB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenic Activation Inflammation | ALPL, APOL4, ASAP2, CALM1, COMMD2, FAT4, PLS3, RALGAPA1 +4 more | View in SCUBA |
| Gamma-delta T cells | Death Receptor Apoptosis Stress | CXCR3, FHL3, GABARAPL2, LDLRAP1, LY6E, PLSCR3, SGSM3, SHISAL2A +4 more |
About the gene
| Synonyms | SIS, SSV |
|---|---|
| Chromosome | 22: 39223359-39244982 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, RAS pathway related proteins |
| Molecular function | Developmental protein, Growth factor, Mitogen |
Function
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.