LDLRAP1 — Low density lipoprotein receptor adaptor protein 1
LDLRAP1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LDLRAP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | AIF1, AK5, APBA2, BEND5, BEX2, C1orf162, CBR3, CYSLTR1 +21 more | View in SCUBA |
| CD8⁺ T cells | Naive/Central Memory T cell maturation | AIF1, ATM, CCR7, FCMR, FOXP1, KLF2, KLF3, LEF1 +7 more | View in SCUBA |
| Gamma-delta T cells | Death Receptor Apoptosis Stress | CXCR3, FHL3, GABARAPL2, LY6E, PDGFB, PLSCR3, SGSM3, SHISAL2A +4 more |
About the gene
| Synonyms | ARH, ARH2, DKFZp586D0624, FHCB1, FHCB2, MGC34705 |
|---|---|
| Chromosome | 1: 25543606-25568886 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cholesterol metabolism, Endocytosis, Lipid metabolism, Steroid metabolism, Sterol metabolism |
Function
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non- polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.