APOL4 — Apolipoprotein L4
APOL4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APOL4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenic Activation Inflammation | ALPL, ASAP2, CALM1, COMMD2, FAT4, PDGFB, PLS3, RALGAPA1 +4 more | View in SCUBA |
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4, DERL1 +29 more | View in SCUBA |
| Monocytes | Immunoproteasome Antigen Processing Innate immunity | APOL1, FBXO6, IFI27, IFI35, LGALS3BP, PSMB8, PSMB9, PSME1 +5 more | View in SCUBA |
About the gene
| Synonyms | APOLIV |
|---|---|
| Chromosome | 22: 36189124-36204840 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Biological process | Lipid transport, Transport |
Function
May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.