Inflammatory Angiogenic Activation
Gene co-expression module in Endothelial
| Category | Inflammation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 13 genes have a known function matching the annotation |
Why this annotation
This module shows the strongest inflammatory upregulation in the batch (delta ~0.29, significant in both UC and CD). Hub gene PDGFB is a key angiogenic/inflammatory mediator secreted by activated endothelium to recruit pericytes. ALPL marks endothelial activation. ASAP2 regulates focal adhesion and vesicle trafficking during endothelial activation. FAT4 (planar cell polarity) and SLC6A6 (osmotic stress response) suggest endothelial remodeling under inflammatory stress. TRAK1/2 regulate mitochondrial trafficking during cellular stress. PLS3 (plastin-3) bundles actin during morphological changes. This module represents an inflammatory angiogenic/activated endothelial response.
Genes
ALPL, APOL4, ASAP2, CALM1, COMMD2, FAT4, PDGFB, PLS3, RALGAPA1, SLC6A6, TRAK1, TRAK2, UACA
Most correlated modules
- Endothelial Junction Identity · correlation 0.91
- Vascular Tone Regulation · correlation 0.84
- EC Inflammatory Activation · correlation 0.84
- WAVE Complex Cytoskeleton · correlation 0.83
- Arterial EC Identity · correlation 0.82
- Endothelial Membrane Transport · correlation 0.81
- Cytoskeletal Scaffolding · correlation 0.81
- Endocytic Membrane Remodeling · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.