FAT4 — FAT atypical cadherin 4
FAT4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FAT4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory Angiogenic Activation Inflammation | ALPL, APOL4, ASAP2, CALM1, COMMD2, PDGFB, PLS3, RALGAPA1 +4 more | View in SCUBA |
| Smooth muscle cells | FOXF2 Mesenchymal Patterning Development | ADAMTS6, APCDD1, BDKRB2, DCHS1, FOXF2, KCNH2, MFAP5, P2RY14 +2 more | View in SCUBA |
About the gene
| Synonyms | CDHF14, CDHR11, FAT-J |
|---|---|
| Chromosome | 4: 125314918-125492932 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted membrane proteins |
| Biological process | Cell adhesion |
Function
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.