Death Receptor Apoptosis
Gene co-expression module in Gamma-delta T cells
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
The two highest-scoring hub genes after SHISAL2A are TRADD (TNF receptor-associated death domain protein, core mediator of TNFR1-induced apoptosis/NF-κB signaling) and TNFRSF10A (DR4/TRAIL receptor 1, death receptor for TRAIL-induced apoptosis). GABARAPL2 is an autophagy receptor linking apoptosis and autophagy. PLSCR3 (phospholipid scramblase 3, mitochondrial apoptosis). LDLRAP1 and TMEM63A have roles in membrane trafficking. CXCR3 mediates T cell homing to inflamed tissues. LY6E is interferon-stimulated. FHL3 (four-and-a-half LIM domain 3). The apoptosis/death receptor theme is the strongest signal in this module, consistent with a TNF/TRAIL death receptor signaling program in γδ T cells.
Genes
CXCR3, FHL3, GABARAPL2, LDLRAP1, LY6E, PDGFB, PLSCR3, SGSM3, SHISAL2A, TMEM63A, TNFRSF10A, TRADD, TTC9
Most correlated modules
- Lymphocyte Tissue Egress · correlation 0.86
- Naïve T Cell State · correlation 0.83
- Coinhibitory Checkpoint · correlation 0.81
- T Cell Survival · correlation 0.77
- Immune Synapse Cytoskeleton · correlation 0.76
- T Cell Development · correlation 0.74
- Effector IFN Response · correlation 0.71
- Translation Initiation · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.