GABARAPL2 — GABA type A receptor associated protein like 2
GABARAPL2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GABARAPL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell activation BCR/AP1/NFKb pathway | ADGRG5, BCAR3, CD86, CLIP2, CNOT2, CTSH, FAS, GPR137B +7 more | View in SCUBA |
| Gamma-delta T cells | Death Receptor Apoptosis Stress | CXCR3, FHL3, LDLRAP1, LY6E, PDGFB, PLSCR3, SGSM3, SHISAL2A +4 more | |
| Innate lymphoid cells | Proteostasis Stress Response Stress | BUB3, ERP29, HIGD2A, NCOR1, NPM1, POLR1D, SOD1, ST13 +2 more | View in SCUBA |
| Lymphatic endothelial | Actomyosin Cytoskeleton Cytoskeletal | BRI3, CD63, CFL1, CHCHD2, COX4I1, EDF1, HINT1, LGALS3 +8 more | View in SCUBA |
| Macrophages | ER Protein Processing Housekeeping | ACTR1A, ANXA7, ATP6AP1, ATP6AP2, ATP6V0B, ATP6V0E1, AUP1, BCAP31 +41 more | View in SCUBA |
| Mucosal-associated invariant T cell | Leukocyte Housekeeping Housekeeping | AP2S1, APRT, ATP5MC2, CCDC85B, EIF3G, ERP29, GMFG, HCST +5 more | |
| Smooth muscle cells | Mitochondrial Housekeeping Housekeeping | APP, COX7A2L, EIF5B, LAMTOR4, NDUFAB1, PGAM1, SPCS2, TMEM14C +2 more | View in SCUBA |
About the gene
| Synonyms | ATG8, ATG8C, GATE-16, GATE16, GEF2 |
|---|---|
| Chromosome | 16: 75566375-75577881 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Autophagy, Protein transport, Transport |
Function
Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.