PHF23 — PHD finger protein 23
PHF23 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHF23's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | T cell Survival T cell maturation | ARFRP1, BCL2L1, C6orf47, CHD9, DAXX, DEF6, DENND2D, DHPS +26 more | |
| Mucosal-associated invariant T cell | Oxidative Stress Response Stress | CDC42EP3, CTU1, EXOSC5, GLRX, GNPDA1, HTATIP2, KRCC1, MLX +11 more |
About the gene
| Synonyms | FLJ16355, MGC2941 |
|---|---|
| Chromosome | 17: 7235029-7239722 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins |
| Biological process | Autophagy, Ubl conjugation pathway |
Function
Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.