T cell Survival
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 35 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 35 genes have a known function matching the annotation |
Why this annotation
Hub genes GIMAP6/8 are lymphocyte-specific GTPases critical for T cell survival and homeostasis. BCL2L1 supports anti-apoptotic survival signaling. PTPN6 (SHP-1) regulates immune receptor signaling thresholds. IRF2 is a transcriptional regulator of interferon responses and lymphocyte identity. KEAP1 senses oxidative/metabolic stress. DAXX links chromatin remodeling to apoptotic signaling. Together these form a T cell homeostatic survival and stress-sensing program consistent with resting gd_T maintenance.
Genes
ARFRP1, BCL2L1, C6orf47, CHD9, DAXX, DEF6, DENND2D, DHPS, ERGIC2, FLI1, FNTA, GIMAP6, GIMAP8, GMPR2, GPR68, GSDMD, HPF1, IL16, IRF2, IVD, KEAP1, LARS1, MLX, MUS81, PDCD10, PHF23, PTPN6, SH2D3C, SYNRG, TMEM106B, TRIM21, TRIM27, TXNDC9, UBLCP1, UPF2
Most correlated modules
- Chromatin Epigenetic Regulation · correlation 0.85
- Interferon Antiviral Response · correlation 0.81
- Actin Remodeling · correlation 0.79
- Antiviral ISG Response · correlation 0.79
- Mitoribosome Small Subunit · correlation 0.77
- Mitochondrial Translation · correlation 0.77
- T Cell Homeostasis · correlation 0.77
- Ubiquitin Protein Quality · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.