CHD9 — Chromodomain helicase DNA binding protein 9
CHD9 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHD9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic Effector CD4 Cytotoxicity | ADAM8, ADRB2, CCL5, DPP4, HIC1, HOPX, IFIT2, ITGA1 +13 more | View in SCUBA |
| Gamma-delta T cells | T cell Survival T cell maturation | ARFRP1, BCL2L1, C6orf47, DAXX, DEF6, DENND2D, DHPS, ERGIC2 +26 more | |
| Innate lymphoid cells | NK Cytotoxic Regulation Cytotoxicity | ARHGAP30, BIN2, CAPN12, CLK1, CTSC, CYB5B, DDX27, DNMT1 +29 more | View in SCUBA |
| Lymphatic endothelial | Chromatin Remodeling DNA/chromatin regulation | BAZ2B, ITFG1, JMJD1C, MICAL3, MPDZ, PACSIN2, PHKB, PLXDC2 +4 more | View in SCUBA |
| Macrophages | DNA Damage Repair Stress | ABCC5, ADAM28, AKAP9, AKNA, ATM, ATP10D, BAZ2A, CREBRF +27 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Epigenetic Regulation DNA/chromatin regulation | ACAP2, APBB1IP, ARHGAP25, ATM, CD247, CLCN3, DDX17, FLI1 +14 more |
About the gene
| Synonyms | BC022889, FLJ12178, KIAA0308 |
|---|---|
| Chromosome | 16: 53054991-53329150 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, DNA-binding, Hydrolase |
| Biological process | Transcription, Transcription regulation |
Function
Probable ATP-dependent chromatin-remodeling factor. Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.