PLVAP — Plasmalemma vesicle associated protein
PLVAP belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLVAP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous Endothelial Identity Endothelial cell development | ABI3, CCDC85B, DOCK4, EHD4, EVA1B, EXOC3L2, HDAC7, ITGA6 +8 more | View in SCUBA |
| Pericytes | Vascular Permeability Migration & adhesion | ABI3, FLT1, GALNT18, ITGA6, NQO1, PRKCH, TM4SF18 | View in SCUBA |
About the gene
| Synonyms | FELS, gp68, PV-1, PV1 |
|---|---|
| Chromosome | 19: 17351450-17377342 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
Function
Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.