Venous Endothelial Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Top hub genes include PLVAP (plasmalemma vesicle-associated protein, canonical marker of fenestrated/venous endothelium), NRP1 (neuropilin-1, VEGF co-receptor expressed on endothelium), MCF2L (Rho GEF), HDAC7 (endothelial-expressed HDAC regulating vascular integrity), ITGA6 (integrin alpha-6), PRKCH (PKC theta, endothelial signaling), NQO1 (NAD(P)H quinone oxidoreductase, oxidative stress response), and DOCK4 (Rac GEF). PLVAP is a defining marker of venous and fenestrated endothelium. NRP1 marks arterial/tip cell endothelium but also venous. The combination with HDAC7 and signaling molecules suggests a venous endothelial identity program. Decreased in inflammation, recovered in remission. Neighbor M25 also has strong venous endothelial identity (EMCN, NOTCH4, ACE), supporting this classification.
Genes
ABI3, CCDC85B, DOCK4, EHD4, EVA1B, EXOC3L2, HDAC7, ITGA6, MCF2L, NQO1, NRP1, PLVAP, PRKCH, RASAL2, RIN1, SHANK3, STXBP1
Most correlated modules
- Arterial EC Identity · correlation 0.86
- Basement Membrane Assembly · correlation 0.82
- Angiogenic Endothelial Identity · correlation 0.81
- IL-27 Receptor Signaling · correlation 0.80
- Glucocorticoid Response · correlation 0.79
- Endothelial Lipid Signaling · correlation 0.77
- Vasoactive GPCR Signaling · correlation 0.76
- Glucocorticoid Response · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.