PPP1R11 — Protein phosphatase 1 regulatory inhibitor subunit 11
PPP1R11 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPP1R11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | IFN-driven ILC1 Activation Inflammation | AFF3, AGPAT5, AKIRIN2, APMAP, ARF6, ARHGEF1, DNAJC1, DYNLT3 +21 more | View in SCUBA |
About the gene
| Synonyms | CFAP255, HCG-V, HCGV, TCTE5, Tctex5 |
|---|---|
| Chromosome | 6: 30066709-30070333 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Protein phosphatase inhibitor, Transferase |
| Biological process | Ubl conjugation pathway |
Function
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.