ARHGEF1 — Rho guanine nucleotide exchange factor 1
ARHGEF1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGEF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | mRNA Splicing Processing RNA processing & translation | BECN1, CCNI, DENND4B, EID1, HNRNPA0, HNRNPDL, KLHDC4, LENG8 +18 more | |
| Innate lymphoid cells | IFN-driven ILC1 Activation Inflammation | AFF3, AGPAT5, AKIRIN2, APMAP, ARF6, DNAJC1, DYNLT3, ELOVL5 +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | Housekeeping Translation Housekeeping | ARHGDIA, CCNI, DAZAP2, EEF2, HLA-A, HLA-B, HNRNPA1, PABPC1 +4 more |
About the gene
| Synonyms | LBCL2, P115-RHOGEF, SUB1.5 |
|---|---|
| Chromosome | 19: 41883173-41930150 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | GTPase activation, Guanine-nucleotide releasing factor |
Function
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as a GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. In lymphoid follicles, may trigger activation of GNA13 as part of S1PR2-dependent signaling pathway that leads to inhibition of germinal center (GC) B cell growth and migration outside the GC niche.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.