AGPAT5 — 1-acylglycerol-3-phosphate O-acyltransferase 5
AGPAT5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AGPAT5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | IFN-driven ILC1 Activation Inflammation | AFF3, AKIRIN2, APMAP, ARF6, ARHGEF1, DNAJC1, DYNLT3, ELOVL5 +21 more | View in SCUBA |
| Macrophages | DNA Replication Metabolism Cell cycle | CBX1, DCK, FADS1, HACD3, HADH, ICMT, IDH2, MTHFD1 +11 more | View in SCUBA |
| Monocytes | DNA Damage Response Stress | ATM, CALM2, DCAF7, FAM13A, GPR155, MEF2C, NLN, NSL1 +4 more | View in SCUBA |
About the gene
| Synonyms | FLJ11210, LPAAT-e, LPAAT-epsilon, LPLAT5 |
|---|---|
| Chromosome | 8: 6708642-6761503 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins |
| Molecular function | Acyltransferase, Transferase |
| Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Function
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor. Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl- CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA. Activity toward lysophosphatidylglycerol not detectable
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.