MAPK-ERK Signaling
Gene co-expression module in Lymphatic endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
BRAF (RAF kinase, MAPK/ERK pathway), RAPGEF2 (Rap1 GEF activating ERK/MAPK), GRB10 (growth factor receptor adaptor linking RTKs to MAPK), and SIK3 (salt-inducible kinase, AMPK family) define a MAPK/kinase signaling module. SSH2 (slingshot phosphatase activating cofilin) links to actin dynamics downstream of MAPK. FNDC3B supports cell adhesion/migration. ARIH1 and FBXO11 are ubiquitin ligases that regulate signaling protein turnover. DENND4A (Rab GEF) and RAPGEF2 add vesicle/Rap signaling. Neighbor context: complements M24 (Hippo/adhesion) and M44 (actin/migration) in a signaling-cytoskeletal neighborhood.
Genes
ARIH1, BRAF, CPNE8, DENND4A, ELF2, FBXO11, FNDC3B, GRB10, NT5C2, PPP1R13B, RAPGEF2, SIK3, SSBP2, SSH2, ZSWIM6
Most correlated modules
- Chromatin Remodeling · correlation 0.96
- ZEB1-driven EMT · correlation 0.95
- Hippo-Adhesion Signaling · correlation 0.94
- Actin-based Migration · correlation 0.92
- Rho/Ras GTPase Regulation · correlation 0.91
- Focal Adhesion Migration · correlation 0.87
- Inflammatory cAMP Response · correlation 0.87
- ECM-driven Migration · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.