PTK7 — Protein tyrosine kinase 7 (inactive)
PTK7 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTK7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Pericyte-like Fibroblast Migration & adhesion | CDK6, CHL1, DSEL, EHD2, ENTPD1, HEPH, ITGB3, NID1 +7 more | View in SCUBA |
| Smooth muscle cells | Fibroblast-like Activation Activation | ANGPTL2, CTSK, EFEMP1, LMO3, MICALL2, PDLIM4, PDPN | View in SCUBA |
About the gene
| Synonyms | CCK4 |
|---|---|
| Chromosome | 6: 43076307-43161719 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
| Biological process | Cell adhesion, Wnt signaling pathway |
Function
Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.