PDLIM4 — PDZ and LIM domain 4
PDLIM4 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PDLIM4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | T Cell Activation TCR Signaling | BIRC3, CRTAM, DUSP5, GADD45G, GEM, HSP90B1, HSPA5, ID3 +9 more | View in SCUBA |
| Endothelial | Inflammatory Stress Response Inflammation | ADI1, APLN, ARL6IP1, ARL6IP4, CCDC88A, DAP, GPR68, HEBP2 +11 more | View in SCUBA |
| Fibroblasts | Lysosomal Stress Response Stress | ARPC1B, ATP6V0B, CTSB, FAM20C, GSTO1, IKBIP, MIF, PKM +3 more | View in SCUBA |
| Lymphatic endothelial | Oxidative Stress Response Stress | ANXA5, ATP6V0B, CCT3, CD59, DRAP1, EIF5A, GPX4, NUPR1 +3 more | View in SCUBA |
| Smooth muscle cells | Fibroblast-like Activation Activation | ANGPTL2, CTSK, EFEMP1, LMO3, MICALL2, PDPN, PTK7 | View in SCUBA |
About the gene
| Synonyms | RIL |
|---|---|
| Chromosome | 5: 132257696-132273454 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted intracellular proteins |
Function
Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton. In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1- containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). Involved in reorganization of the actin cytoskeleton and in regulation of cell migration. In response to oxidative stress, binds to NQO1, which stabilizes it and protects it from ubiquitin-independent degradation by the core 20S proteasome. Stabilized protein is able to heterodimerize with isoform 1 changing the subcellular location of it from cytoskeleton and nuclei to cytosol, leading to loss of isoforms 1 ability to induce formation of actin stress fibers. Counteracts the effects produced by isoform 1 on organization of actin cytoskeleton and cell motility to fine-tune actin cytoskeleton rearrangement and to attenuate cell migration
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.