CTSK — Cathepsin K
CTSK belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTSK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Proteolytic Fibroblast State ECM remodeling | ANXA2, EMP3, LGALS3, MPZL1, PCOLCE, ROBO1, S100A10, S100A16 +3 more | View in SCUBA |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
| Pericytes | Stromal ECM Production ECM production | ABCA8, CCL11, CFD, DCN, FBLN1, LUM, MFAP4, VCAN | View in SCUBA |
| Smooth muscle cells | Fibroblast-like Activation Activation | ANGPTL2, EFEMP1, LMO3, MICALL2, PDLIM4, PDPN, PTK7 | View in SCUBA |
About the gene
| Synonyms | CTSO, CTSO2, PKND, PYCD |
|---|---|
| Chromosome | 1: 150794880-150809577 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Protease, Thiol protease |
Function
Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.