SEMA5A — Semaphorin 5A
SEMA5A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEMA5A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene Nuclear Transcripts Technical artifact | ADAMTSL1, KHDRBS2, LIN7A, OPCML, PAQR5, PIGZ, PLCL1, RALYL +3 more | View in SCUBA |
| Pericytes | Pericyte Identity Cytoskeletal | ABCC9, ARHGAP42, ARHGEF17, ECM2, EDNRA, EGFLAM, GJC1, LHFPL6 +2 more | View in SCUBA |
About the gene
| Synonyms | SEMAF, semF |
|---|---|
| Chromosome | 5: 9035033-9546075 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Neurogenesis |
Function
Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.