Mature Colonocyte Metabolism
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 18 of 46 genes have a known function matching the annotation |
Why this annotation
Hub genes HMGCS2, EHHADH, CROT, ACSF2, ACADS define peroxisomal and mitochondrial fatty acid oxidation and ketogenesis. NR1H3 (LXR-alpha) is a master lipid metabolism regulator. CA1, SLC26A2, CHP2, SLC16A1 reflect mature colonocyte ion/solute transport. B4GALNT2, GCNT2 are colonocyte-specific glycosyltransferases. SELENBP1 is a mature colonocyte marker. The module is strongly enriched in mat_colono and significantly downregulated during inflammation, consistent with loss of mature colonocyte metabolic identity in IBD. Strong coherence supports a single tight program.
Genes
Most correlated modules
- Fatty Acid Oxidation · correlation 0.85
- Lipid Xenobiotic Metabolism · correlation 0.73
- Colonocyte Solute Transport · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.