EDNRA — Endothelin receptor type A
EDNRA belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EDNRA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | Pericyte Identity Cytoskeletal | ABCC9, ARHGAP42, ARHGEF17, ECM2, EGFLAM, GJC1, LHFPL6, MYO1B +2 more | View in SCUBA |
| Smooth muscle cells | Vasoconstrictor Signaling Contractility | ARHGAP29, ATP10A, BBX, CDK18, CSRP2, GPAT2, NR3C1, NUDT4 +4 more | View in SCUBA |
About the gene
| Synonyms | ET-A, ETA-R, hET-AR |
|---|---|
| Chromosome | 4: 147480917-147544954 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.