SIPA1 — Signal-induced proliferation-associated 1
SIPA1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SIPA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | gd T Cell Identity T cell maturation | AKAP17A, CNNM3, GALNT11, KCNA3, MECP2, PIEZO1, PLXNC1, RASGEF1A +6 more | |
| Macrophages | Endosomal Membrane Trafficking Vesicular traficking | A2M, AP1B1, ARHGAP4, ARHGEF6, ATG4C, B3GNT7, CRTAP, ETV5 +20 more | View in SCUBA |
About the gene
| Synonyms | SPA1 |
|---|---|
| Chromosome | 11: 65638101-65650918 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | GTPase activation |
Function
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.