Endosomal Membrane Trafficking
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 29 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 29 genes have a known function matching the annotation |
Why this annotation
AP1B1 (AP-1 clathrin adaptor), SNX18 (sorting nexin/endosomal tubulation), MARCHF1 (MARCH1 E3 ligase mediating MHC-II ubiquitination and endosomal sorting), TMEM106B (lysosomal membrane protein), ARHGAP4/ARHGEF6 (Rho GTPase regulators of vesicle trafficking), PTPN18 (endosomal phosphatase), SLCO2B1 (membrane transporter). This module captures endosomal membrane trafficking and vesicle sorting in macrophages, with MARCHF1 linking to MHC regulation.
Genes
A2M, AP1B1, ARHGAP4, ARHGEF6, ATG4C, B3GNT7, CRTAP, ETV5, FYB1, FZD1, GASK1B, GLMP, IDH1, LGMN, MARCHF1, MAT2B, MGAT4A, OTULINL, PFKFB2, PRNP, PTER, PTPN18, SAMHD1, SDC3, SIPA1, SLCO2B1, SNX18, TMEM106B, TMEM19
Most correlated modules
- Myeloid Innate Signaling · correlation 0.96
- Retromer Endosomal Sorting · correlation 0.95
- Innate Antiviral Sensing · correlation 0.94
- TGF-beta Signaling · correlation 0.94
- Lysosomal Hydrolase Program · correlation 0.90
- Anti-inflammatory Response · correlation 0.89
- Myeloid Differentiation Identity · correlation 0.89
- Mixed Regulatory Signaling · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.