ARHGEF6 — Rac/Cdc42 guanine nucleotide exchange factor 6
ARHGEF6 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGEF6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Endosomal Membrane Trafficking Vesicular traficking | A2M, AP1B1, ARHGAP4, ATG4C, B3GNT7, CRTAP, ETV5, FYB1 +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Histone Modification DNA/chromatin regulation | ANKRD17, ASH1L, CLTC, FAM120B, KDM4C, NRDC, PCM1, RELCH +3 more |
About the gene
| Synonyms | alpha-PIX, alphaPIX, Cool-2, Cool2, KIAA0006, MRX46 |
|---|---|
| Chromosome | X: 136665547-136780932 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Acts as a RAC1 guanine nucleotide exchange factor (GEF)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.